Can I Take Magnesium Glycinate and Vitamin D3 Together?

As a fitness professional, I often get asked about magnesium glycinate and vitamin D3. Both supplements have been available on the market for decades, and their benefits are well-known.

Therefore, the question of whether they can be taken together naturally arises.

The short answer is yes, but as with most things related to health and supplements, it’s a bit more complicated than that.

So, sit tight and stay tuned! I will provide you with all the information you need about these two supplements. By the end, you’ll have a thorough answer to, “can I take magnesium glycinate and vitamin D3 together?”

What is Magnesium Glycinate?

Magnesium glycinate might sound complicated, but it is actually a combination of magnesium and the amino acid glycine.

To fully understand the benefits of magnesium glycinate, it is important to know about magnesium and glycine as individual components. Magnesium is an essential mineral that plays a crucial role in various biochemical reactions in the body. Magnesium deficiency can lead to several health problems.

Glycine is an amino acid linked to the release of growth hormones and may have potential benefits for conditions such as schizophrenia. (1) Because it is non-essential – the body produces it, I prefer glycine to be part of another supplement, not a separate one.

Benefits of Magnesium Glycinate

The unique properties of magnesium glycinate are closely related to bioavailability. In addition, it has numerous other health benefits similar to most other forms of magnesium.

Most people think of magnesium when they experience cramps and muscle weakness. This is certainly one of the main reasons magnesium, including transdermal sprays, is a popular supplement among athletes.

Recovery and sleep are next in a long line of benefits. Magnesium relaxes you, and therefore you can sleep better.

The digestive tract and skeletal muscle system cannot function properly without magnesium.

Is it really necessary to mention more benefits after all these? If so, it is best to read our extensive guide about this supplement and let’s move on to another star of this article – vitamin D.

What is Vitamin D3?

Vitamin D3, also known as cholecalciferol, is a fat-soluble vitamin that plays a crucial role in the human body. There are different forms of vitamin D, and along with D3, the most common is ergocalciferol (vitamin D2.)

The best way for your body to synthesize vitamin D is to be exposed to the sun, of course, when the UV radiation is not too high. When exposed to sunlight, the skin produces it (it is crucial to expose arms and face.) (2)

Along with sunlight and supplements, food is also a source of vitamin D3. The best sources are milk, eggs, and fish. If you consume sufficient amounts of these foods and get at least 15 minutes every day in the sunlight, the level of D3 in your body should be good.

Living in an area with limited sunlight or following a strict plant-based diet increases your risk of deficiency.

Benefits of Vitamin D3

Vitamin D3 generated all the buzz during the COVID-19 pandemic. I remember going to the pharmacy just to see empty shelves. It was downright impossible to find this supplement back then.

Faster and better recovery from coronavirus is just one of the many benefits of this vitamin. (3)

Generally, the main benefit is the successful absorption of calcium, essential for strong bones and teeth. Next, it also supports immune system function, helps regulate insulin levels, and promotes healthy muscle function.

That’s not all. It reduces inflammation, helps the cardiovascular system, and even decreases the risk of cancer.

It has been noticed that people with low vitamin D levels are more prone to depression and anxiety – another reason to pay attention to vitamin D intake.

A pregnant woman should also take it to support fetus growth.

Can I Take Magnesium Glycinate and Vitamin D3 Together?

Yes, it is totally safe for healthy adults to take magnesium glycinate and vitamin D3 together. That combo can even lead to additional benefits, but more on that later.

The good news is that both supplements are unlikely to cause any adverse effects when taken together in recommended dosages. Of course, using too much of either supplement can lead to unwanted side effects, which are usually mild.

As with any supplement, it’s best to consult a healthcare professional before combing them, but in general, you have nothing to worry about. Mg plus D3 is one of the best-researched combinations.

Will Taking Magnesium Glycinate and Vitamin D3 Together Lead to Additional Benefits?

Usually, I can’t tell you more about the synergistic effect of taking two specific supplements because the evidence is primarily circumstantial and coincidental. That’s why we examine how the two supplements work separately and whether they trigger side effects together.

But this time is different. A study backs up the opinion that taking magnesium and vitamin D3 together can lead to additional benefits. (4)

More research is needed to prove whether there are more benefits to taking these supplements together, but the findings so far are very encouraging.

Is it Worth it to Take Magnesium Glycinate and Vitamin D3 Together?

Let’s get one thing perfectly clear – the decision to take magnesium glycinate and vitamin D3 together or any other supplement is a personal one.

However, I advise taking them together, especially in winter. They are part of my supplement regimen during most of the year, both because of their separate benefits and the aforementioned synergistic effect – serum concentrations of vitamin D are higher when taken with magnesium than when taken alone.

It is something that unequivocally suggests that you should combine them.

If you have any doubts or think this combination can harm you somehow, consult a doctor or a registered dietitian.


It’s no secret that supplements can be confusing, and it’s tough to know which ones you should use.

Taking magnesium glycinate and vitamin D3 together can be very beneficial. From improved sleep quality to better bone health, these supplements can truly make a difference in your overall well-being.

Ultimately, the decision to take minerals and vitamins is a personal one. It’s important to remember that while they can provide benefits, they should never replace a healthy diet or lifestyle.


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